منابع مشابه
Immunotoxicology in the pharmaceutical industry.
Development of an immunotoxicology program within the pharmaceutical industry is described. With few guidelines in the area and a multitude of factors to consider, a basic screen for evaluating immune competence in species routinely used in toxicologic studies has been proposed. The future of immunotoxicology depends upon the ability of the selected immune function tests to be predictive of hum...
متن کاملImmunotoxicology of beryllium lung disease.
Beryllium induces non-caseating granulomatous inflammation in humans exposed to the metal dust or fumes in both occupational and non-occupational settings. The resulting condition, chronic beryllium disease (CBD), affects principally the lungs, lymphatics, and skin and continues to plague modern industry. Beryllium exerts several important immunotoxic effects, including induction of a beryllium...
متن کاملModels of respiratory immunotoxicology and host resistance.
The immune system consists of a vast network of lymphoid and nonlymphoid cells, communicating via messenger molecules to create a functional immune system to protect against disease. This network, while interconnected via mediator molecules, contains compartmentalized units especially equipped to defend against insults to the integrity of the immune system. The pulmonary immune system is an exa...
متن کاملAlterations in regulatory T-cells: rediscovered pathways in immunotoxicology.
In addition to the effector T-cells subsets, T-cells can also differentiate into cells that play a suppressive or regulatory role in adaptive immune responses. The cell types currently identified as regulatory T-cells (T(regs)) include natural or thymic-derived T(regs), T-cells which express Foxp3(+)CD25(+)CD4(+) and can suppress immune responses to autoreactive T-cells, as well as inducible T(...
متن کاملImmunotoxicology in Marine Invertebrates: Effects of Manganese on Immune Response
Manganese, Mn, is an abundant element in nature, particularly in soft bottom sediments of the oceans and in bedrock. The metal is predominantly bound to the sediment in the colloid state, MnO2. Eutrophication caused by the high nutrient load in coastal waters together with over-fishing cause cascade effects in the ecosystem increasing the algal blooms and enhancement of hypoxic condition over l...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1987
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262338701500313